Melanoma is the deadliest form of skin cancer, responsible for thousands of deaths each year; but early detection can dramatically increase survival rates. Now, scientists have developed an advanced artificial intelligence (AI) model that can detect melanoma more accurately by combining skin images with patient metadata. The study achieved 94.5% accuracy, marking a breakthrough in AI-powered early detection of melanoma, thereby advancing smart healthcare systems.
Melanoma remains one of the hardest skin cancers to diagnose because it often mimics harmless moles or lesions. While most artificial intelligence (AI) tools rely on dermoscopic images alone, they often overlook crucial patient information (like age, gender, or where on the body the lesion appears) that can improve diagnostic accuracy. This highlights the importance of multimodal fusion models that can enable high precision diagnosis.
To bridge that gap, Professor Gwangill Jeon from the Department of Embedded Systems Engineering, Incheon National University, South Korea, in collaboration with the University of West of England (UK), Anglia Ruskin University (UK), and the Royal Military College of Canada, created a deep learning model that integrates patient data and dermoscopic images. The study was made available online on June 06, 2025, and will be published in Volume 124 of the journal Information Fusion on December 01, 2025.
“Skin cancer, particularly melanoma, is a disease in which early detection is critically important for determining survival rates,” says Prof. Jeon. “Since melanoma is difficult to diagnose based solely on visual features, I recognized the need for AI convergence technologies that can consider both imaging data and patient information.”
Using the large-scale SIIM-ISIC melanoma dataset, which contains over 33,000 dermoscopic images paired with clinical metadata, the team trained their AI model to recognize subtle links between what appears on the skin and who the patient is. The model achieved 94.5% accuracy and an F1-score of 0.94, outperforming popular image-only models such as ResNet-50 and EfficientNet.
The researchers also performed feature importance analysis to make the system more transparent and robust. Factors like lesion size, patient age, and anatomical site were found to contribute strongly for accurate detection. These insights can help doctors understand and provide a roadmap to trust the diagnosis performed by AI.
Prof. Jeon says, “The model is not merely designed for academic purposes. It could be used as a practical tool that could transform real-world melanoma screening. This research can be directly applied to developing an AI system that analyzes both skin lesion images and basic patient information to enable early detection of melanoma.”
In the future, the model could power smartphone-based skin diagnosis applications, telemedicine systems, or AI-assisted tools in dermatology clinics, helping reduce misdiagnosis rates and improve access to care. Prof. Jeon explains, “The study represents a step forward toward personalized diagnosis and preventive medicine through AI convergence technology.”
The study highlights how multimodal AI can bridge the gap between machine learning and clinical decision-making, paving the way for more accurate, accessible, and trustworthy skin cancer diagnostics.
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Reference
DOI: 10.1016/j.inffus.2025.103304
