The search for more efficient tests of pharmaceuticals without animal models is taking a stride forward, with a new technology being developed in the US called Organs-on-Chips. The new miniature platform and software, which mimic the mechanical and molecular characteristics of human organs, were developed by bioengineers from the Wyss Institute for Biologically Inspired Engineering at Harvard University.
The device, about the size of a small computer memory stick, is created using microchip-manufacturing techniques. It features a porous flexible membrane that separates two channels at the center of the device. The channels are filled with living human cells and tissues cultured in a fluid that mimics the environment inside the human body. Micro-engineering and automated instrumentation allows the system to perform real-time analysis of biochemical, genetic and metabolic functions within single cells.
via Gizmag
